Effects of Demineralized Dentin Matrix Used as an rhBMP-2 Carrier for Bone Regeneration
نویسندگان
چکیده
منابع مشابه
Liposomal Delivery of Demineralized Dentin Matrix for Dental Tissue Regeneration.
Current dental restorations have short longevity, and consequently, there is a need for novel tissue engineering strategies that aim to regenerate the dentin-pulp complex. Dentin matrix contains a myriad of bioactive growth factors and extracellular matrix proteins associated with the recruitment, proliferation, and differentiation of dental pulp progenitor cells. In this study, we show that de...
متن کاملDemineralized dentin matrix scaffolds for alveolar bone engineering
From the point of view of implant dentistry, this review discusses the development and clinical use of demineralized dentin matrix (DDM) scaffolds, produced from the patient's own extracted teeth, to repair alveolar bone defects. The structure and the organic and inorganic components of DDM are presented to emphasize the similarities with autogenous bone. Studies of DDM properties, such as oste...
متن کاملBone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles
PURPOSE This study examined the osteoinductive activity of demineralized human dentin matrix for nude mice. METHODS Twenty healthy nude mice weighing about 15 to 20 g were used for study. Demineralized human dentin matrix was prepared and implanted into the dorsal portion of nude mice (subcutaneous), which were sacrificed at two, four, and eight weeks after demineralized dentin matrix graftin...
متن کاملDemineralized bone matrix used for direct pulp capping in rats
OBJECTIVES To evaluate the wound healing process following direct pulp capping with demineralized bone matrix (DBM) and calcium hydroxide (Ca(OH)2). METHODS Fifty 8-weeks-old SPF Wistar male rats were divided into two groups: one was the DBM treated group, and the other was the Ca(OH)2 treated group. Pulpotomy was performed on the maxillary first molar of one side of each rat, and the another...
متن کاملEffect of rhBMP-2 Immobilized Anorganic Bovine Bone Matrix on Bone Regeneration
Anorganic bovine bone matrix (Bio-Oss®) has been used for a long time for bone graft regeneration, but has poor osteoinductive capability. The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) has been suggested to overcome this limitation of Bio-Oss®. In the present study, heparin-mediated rhBMP-2 was combined with Bio-Oss® in animal experiments to investigate bone formation perf...
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ژورنال
عنوان ژورنال: Journal of Hard Tissue Biology
سال: 2014
ISSN: 1341-7649,1880-828X
DOI: 10.2485/jhtb.23.415